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Acute mycotoxin effects are characterized by rapid onset and toxic response in the target organ most affected by the offending agent

This tissue-selective targeting strategy, when RapaLink-1 is combined with RapaBlock, has been shown to prolong survival in mouse models of glioblastoma, highlighting its potential for treating brain tumors while minimizing systemic toxicity

was supported in part by a Fellowship from the Swedish Wenner-Gren Foundation, #GFOv2025-0020

289 At the same time, the promotion of CD8 + T cell activation and recruitment and significant inhibition of MDSCs generation and recruitment were observed in models treated with L-DON and JHU-083

For example, phagocytic (phago) tumor-associated macrophages (TAMs) were significantly enriched in meningiomas relative to the adjacent dura (Fig